Due to higher ratios of n-6/n-3 in modern diets, larger quantities of LA- and AA-derived lipid mediators are produced, becoming the main causes of the formation of thrombus and atheroma, the allergic and inflammatory disorders, and the proliferation of cells, as well as the hyperactive endocannabinoid system. The volume of n-6 PUFAs is largely exceeding the volume of n-3PUFAs. Overconsumption of n-6 PUFAs with low intake of n-3 PUFAs is highly associated with the pathogenesis of many modern diet-related chronic diseases. It is indicated that supplementation with â -3 and â-6 fatty acids may offer significant protection for postmenopausal women against cardiovascular diseases and occlusive thrombotic events by reducing platelet reactivity. Omega-6 fatty acids are essential for our brain health, growth, and metabolism, among other things, and they’re found in foods like nuts and seeds. Except for DGLA, n-6 PUFA-derived lipid mediators enhance inflammation, platelet aggregation, and vasoconstriction, while those of n-3 inhibit inflammation and platelet aggregation and enhance vasodilation. In particular there is evidence that exposure to excess omega-6 PUFA before birth or in early infancy may be responsible for promoting fat cell formation early. The lipid mediators produced from their oxidative metabolism perform opposing (antagonistic) functions in the human body. Omega-3 and Omega-6 PUFAs are competitively metabolized by the same set of desaturation, elongation, and oxygenase enzymes. In both Omega families, many forms of PUFAs exist: α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) from the n-3 family and linoleic acid (LA), dihomo- γ-linolenic acid (DGLA), and arachidonic acid (AA) from the n-6 family are the important PUFAs for human health. 2,4,5 The Dietary Guidelines for Americans 2020-2025 recommends that adults consume 1.1-1.6 grams of omega-3s per day. This means that you should aim to eat 1 gram of omega-3s for every 4 grams of omega-6. The body needs fatty acids (essential fatty acids) to work properly. When eaten in moderation and in place of saturated fats, omega-6 fatty acids can be good for the heart and appear to protect against heart disease. Omega-3 (n-3) and Omega-6 (n-6) PUFAs are the two known important families in human health and nutrition. Despite varying conclusions in the literature, in general, the ideal n-6:n-3 fatty acid ratio is 4:1. Omega-6 fatty acids are a type of polyunsaturated fat found in vegetable oils, nuts and seeds. Polyunsaturated fatty acids (PUFAs) contain ≥2 double-bond desaturations within the acyl chain. Overall, canola oil has the most balanced fatty acid composition, not only due to a good omega-6:omega-3 ratio, but also because it contains a high percentage.

Omega 6 fatty acids